Related Experiment Video
Updated: Jun 6, 2026

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
Published on: March 28, 2025
[Control of bone remodeling by nervous system. Nerve distribution and pain in bone tissue]
Kousuke Iba1, Toshihiko Yamashita
1Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Abstract:
The nerve fibers extensively innervate bone such as periosteum, compact and trabecular bone, and bone marrow space. Regarding as nerve fibers, there are myelinated fibers as Aβ and Aδ fibers, and unmyelinated fibers as C fiber, further, sympathetic nerve fibers also innervated bone tissue. In addition to nerve fibers, several receptors such as nociceptors at the terminal of the fibers, and released many kinds of neuropeptides were identified in the bone. On the other hand, most of roles concerning the nerve fibers, receptors and neuropeptides in bone were still unknown. Recently, bone pain of musculoskeletal disease is recognized to be related pathological condition at increasing bone resorption. It is thought to be a mechanism that a highly acidic condition at a bone compartment due to proton released from activated osteoclast stimulated acid sensing receptor as a nociceptor, and afferent signal induced bone pain.
Related Concept Videos
Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nociception
Bone Remodeling
Bone Remodeling and Repair
Pain
Organization of the Nervous System
The CNS, comprising the brain and spinal cord, houses billions of neurons. The brain is housed in the skull, while the spinal cord is linked to the brain through the foramen magnum of the occipital bone and is surrounded by the protective structure of the vertebral column. It is responsible for processing various...

