Related Experiment Video
Updated: Jun 6, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
Published on: March 1, 2022
[Control of bone remodeling by nervous system. Regulation of bone metabolism by peripheral nervous system]
1Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, Aichi-Gakuin, Japan.
Abstract:
Bone is richly innervated with adrenergic and peptidergic nerve terminals, and these play important roles in bone remodeling. Recent study confirmed a functional nerve-osteoblastic interplay by using an in vitro co-culture model comprising mouse osteoblastic cells and neurite-spouting mouse superior cervical ganglia. This indicates that nerve-osteoblastic cell cross-talk can occur for the dynamic regulation of local bone metabolism by peripheral nervous system. This review summarized both in vivo and in vitro evidences implicating peripheral neuron action in bone metabolism.
Related Concept Videos
Bone Remodeling
Osteoclasts in Bone Remodeling
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling and Repair
Nervous System
Extending...
Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
