Related Experiment Video
Updated: Jun 6, 2026
04:00
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
Published on: November 15, 2024
Major vessel involvement in Behçet's disease: an update
Kenneth T Calamia1, Michael Schirmer, Melike Melikoglu
1Mayo Clinic College of Medicine, Jacksonville, FL 32225, USA. calamia@mayo.edu
Current Opinion in Rheumatology
|December 3, 2010
Summary
Large vessel vasculitis in Behçet disease requires early detection and aggressive treatment to reduce complications. Advances in medical and surgical care are improving outcomes for affected patients.
Area of Science:
- Rheumatology
- Vascular Medicine
- Immunology
Background:
- Behçet disease can manifest with large vessel vasculitis, posing significant risks.
- This subgroup of patients faces high morbidity and mortality.
- Early identification and management are crucial for patient care.
Purpose of the Study:
- To review current knowledge on large vessel vasculitis in Behçet disease.
- To highlight recent advancements in understanding and managing these complications.
- To emphasize the importance of risk recognition and early intervention.
Main Methods:
- Literature review of recent contributions to the field.
- Analysis of current understanding of pathophysiology.
- Overview of evolving treatment strategies.
Main Results:
- Vasculo-Behçet disease presents with thromboses, stenoses, occlusions, and aneurysms.
- Inflammation of the vessel wall is a key factor in clot formation.
- Endovascular procedures are increasingly utilized for aneurysm treatment.
Conclusions:
- Improved recognition and aggressive treatment are reducing mortality.
- Novel surgical techniques are contributing to better patient outcomes.
- The prognosis for large vessel vasculitis in Behçet disease is improving.
Related Concept Videos
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:24Esophageal Varices-I: Introduction
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
01:28Esophageal Varices-II: Clinical Features and Management
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:22Portal Hypertension
Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...