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Hemostatic alterations with exercise conditioning in NIDDM.

W G Hornsby1, K A Boggess, T J Lyons

  • 1Charleston Veterans Administration Medical Center, Charleston, South Carolina.

Diabetes Care
|February 1, 1990
PubMed
Summary
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Regular exercise training in men with non-insulin-dependent diabetes mellitus (NIDDM) significantly reduced plasma fibrinogen and fibronectin. This suggests exercise may offer antithrombotic benefits for NIDDM patients.

Area of Science:

  • Exercise physiology
  • Cardiovascular health
  • Metabolic disorders

Background:

  • Non-insulin-dependent diabetes mellitus (NIDDM) is associated with increased thrombotic risk.
  • Coagulation and fibrinolysis parameters are crucial in managing diabetes-related complications.

Purpose of the Study:

  • To investigate the effects of exercise training on coagulation and fibrinolysis in men with NIDDM.
  • To determine if exercise conditioning can mitigate thrombotic risks in this population.

Main Methods:

  • 13 men with NIDDM underwent 12-14 weeks of exercise training (30 min, 3x/week, 70% VO2max).
  • Coagulation and fibrinolysis parameters were measured pre- and post-training.
  • Key parameters assessed included fibrinogen, fibronectin, plasminogen, and fibrinolytic activity.

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Main Results:

  • Exercise training improved VO2max by 12.5% but did not significantly alter body weight, body fat, blood pressure, or lipid profiles.
  • Plasma fibrinogen and fibronectin levels were significantly reduced post-training (P < 0.02).
  • No significant changes were observed in other coagulation factors, hematocrit, or fibrinolytic activity assays.

Conclusions:

  • Exercise conditioning in NIDDM patients leads to a significant reduction in plasma fibrinogen and fibronectin.
  • These reductions suggest potential antithrombotic effects of exercise in NIDDM.
  • Reduced plasma fibrinogen provides a rationale for incorporating exercise training into NIDDM management.