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Related Concept Videos

Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

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Related Experiment Video

Updated: Jun 6, 2026

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
08:26

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Published on: June 14, 2018

Routine interferon-neutralising antibody testing in patients with relapsing-remitting multiple sclerosis.

P Foley1, P Reilly, A Coulson

  • 1Ninewells Hospital, Dundee DD19SY, UK.

The Journal of the Royal College of Physicians of Edinburgh
|December 3, 2010
PubMed
Summary
This summary is machine-generated.

Routine testing for neutralising antibodies (NABs) against beta-interferon (IFN-ß) in multiple sclerosis patients is feasible and provides valuable data. This approach can inform treatment decisions and potentially improve patient outcomes in high-prevalence areas.

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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Area of Science:

  • Neurology
  • Immunology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) is a significant cause of disability in young adults.
  • Scotland has the highest prevalence of MS in Europe.
  • Beta-interferon (IFN-ß) is a common disease-modifying therapy for relapsing-remitting MS.

Purpose of the Study:

  • To evaluate the implementation and implications of routine neutralising antibody (NAB) testing for IFN-ß in MS patients.
  • To assess the prevalence of NABs in a Scottish MS population.
  • To comment on the cost-effectiveness and clinical utility of routine NAB testing.

Main Methods:

  • Serum samples were collected from 105 patients over two years in NHS Tayside.
  • NAB testing was performed to detect antibodies against IFN-ß.
  • Data on NAB positivity and its implications were analyzed.

Main Results:

  • 35 out of 105 patients (33.3%) tested positive for NABs.
  • Routine testing provided data on antibody prevalence within the study cohort.
  • The study discusses the cost and broader implications of implementing routine NAB testing.

Conclusions:

  • Routine NAB testing for IFN-ß in MS patients is a viable strategy.
  • Understanding NAB prevalence is crucial for optimizing MS treatment efficacy.
  • Further evaluation is needed to establish universal protocols for NAB testing in MS management.