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Infliximab in relapsing polychondritis
Ana Paula Soares de Barros1, Nilton Akeshi Nakamura, Thiara de Freitas Borges Santana
139th Rheumatology Ward, Santa Casa da Misericórdia do Rio de Janeiro.
Abstract:
Relapsing polychondritis (RP) is a rare systemic disease of unknown etiology, characterized by recurrent inflammation of cartilaginous structures and other connective tissues, including the ears, nose, joints, respiratory tract, and others. Due to the presence of typical signs and symptoms, biopsy is seldom necessary. Treatment includes corticosteroids, occasionally associated with immunosuppressive agents, but refractory cases are described. Recent reports suggest that anti-TNF agents, such as infliximab, may be of value in patients who do not respond to conventional therapy, but experience with this treatment is scarce. In this paper, the authors report the case of a patient with RP refractory to combined treatment with corticosteroids and immunosuppressive agents, who showed a good response to infliximab.
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