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Allergic rhinitis with negative skin tests
Michael L Alvares1, David A Khan
1Department of Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8859, USA.
Current Allergy and Asthma Reports
|December 3, 2010
Summary
Localized allergic rhinitis, where patients react to allergens in the nose but not on skin tests, remains poorly understood. Further research is needed to clarify its diagnosis and treatment.
Area of Science:
- Allergy and Immunology
- Rhinology
Background:
- A subset of patients exhibit positive nasal allergen provocation despite negative skin prick tests.
- This phenomenon suggests the possibility of localized allergic rhinitis.
- However, the prevalence of this condition is highly variable across studies.
Purpose of the Study:
- To review the current understanding and challenges associated with localized allergic rhinitis.
- To highlight the need for standardized diagnostic criteria and further research.
Main Methods:
- Review of existing literature on nasal provocation tests and allergic rhinitis.
- Analysis of factors contributing to variability in reported prevalence rates.
Main Results:
- Prevalence estimates for localized allergic rhinitis range widely (0% to 100%) in skin test-negative individuals.
- Methodological differences, including allergen source, concentration, and positive challenge criteria, significantly impact prevalence findings.
Conclusions:
- The concept of localized allergic rhinitis faces diagnostic and methodological challenges.
- Standardization of diagnostic tests and further investigation into immunopathology are essential for clinical application.
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