Drug Anaphylaxis

Anaphylaxis is a systemic clinical syndrome that rapidly evolves after an exposure to an inciting agent activates effector cells such as mast cells and basophils. Anaphylaxis can be triggered by a wide variety of agents, including drugs. Over the past decade, our understanding of drug-induced anaphylaxis (DIA) has become dramatically more nuanced, with a growing appreciation of multiple endotypes resulting in the phenotype of anaphylaxis. This review will discuss epidemiology, clinical features, mechanisms, clinical evaluation, and management of DIA.