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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

182
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Measuring Local Anaphylaxis in Mice
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Drug Anaphylaxis.

Timothy G Chow1, Anna Cheng1, Cynthia Haddad1

  • 1Division of Allergy and Immunology, Departments of Internal Medicine and Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard F04.206, Dallas, TX 75390-9063, USA.

Immunology and Allergy Clinics of North America
|April 3, 2026
PubMed
Summary
This summary is machine-generated.

Drug-induced anaphylaxis (DIA) is a severe allergic reaction. This review covers its epidemiology, features, mechanisms, evaluation, and management, highlighting recent advances in understanding its diverse causes and presentations.

Keywords:
AnaphylaxisDrug allergyHypersensitivity reactionIgE-mediatedImmediate reaction

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Area of Science:

  • Clinical Immunology
  • Allergy and Immunology
  • Pharmacology

Background:

  • Anaphylaxis is a rapid, systemic allergic reaction triggered by various agents.
  • Drugs are a common cause of anaphylaxis, necessitating a deeper understanding of drug-induced anaphylaxis (DIA).

Purpose of the Study:

  • To provide a comprehensive review of drug-induced anaphylaxis (DIA).
  • To discuss the epidemiology, clinical manifestations, underlying mechanisms, diagnostic approaches, and therapeutic strategies for DIA.

Main Methods:

  • Literature review focusing on recent advancements in understanding DIA.
  • Synthesis of current knowledge on DIA pathophysiology, clinical presentation, and management.

Main Results:

  • Recognition of multiple endotypes contributing to the anaphylaxis phenotype.
  • Increased nuance in understanding the diverse triggers and mechanisms of DIA.

Conclusions:

  • Effective management of DIA requires understanding its complex etiology and varied clinical presentations.
  • Continued research into DIA endotypes will refine diagnostic and therapeutic approaches.