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Related Concept Videos

RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...

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Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Web-based tools for studying RNA structure and function.

Ajish D George1, Scott A Tenenbaum

  • 1Department of Biomedical Sciences, School of Public Health, Gen∗NY∗Sis Center for Excellence in Cancer Genomics, University at Albany-SUNY, Rensselaer, NY, USA. ajishg@gmail.com

Methods in Molecular Biology (Clifton, N.J.)
|December 3, 2010
PubMed
Summary
This summary is machine-generated.

Discovering RNA structural motifs is crucial for understanding RNA-protein interactions. This study provides a comprehensive list of web-based resources for identifying these important RNA elements.

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Last Updated: Jun 6, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
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RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Structural Biology

Background:

  • Functional RNA motifs are often conserved at the structural level, not just sequence.
  • Understanding RNA structural motifs is key to deciphering RNA-protein interactions.
  • Identifying RNA elements targeted by RNA-binding proteins is a major challenge in RNA biology.

Purpose of the Study:

  • To present a comprehensive list of web-based resources for studying RNA structural motifs.
  • To survey informatic tools that aid in the identification of RNA-based structural and regulatory motifs.
  • To facilitate research in RNA biology by highlighting available computational resources.

Main Methods:

  • Compilation of web-based resources.
  • Survey of bioinformatics tools.
  • Literature review of RNA motif identification strategies.

Main Results:

  • A curated list of web resources for RNA motif analysis.
  • An overview of informatic tools for RNA structural motif discovery.
  • Identification of key resources for RNA-binding protein target studies.

Conclusions:

  • Web-based resources and bioinformatics tools are essential for advancing RNA motif research.
  • Characterizing RNA structural motifs is critical for understanding RNA function and regulation.
  • Further development of informatic resources will accelerate discoveries in RNA biology.