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Updated: Jun 6, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Endothelial dysfunction and sympathetic nervous system activation in young patients with essential arterial
Agnieszka M Kuklinska1, Barbara Mroczko, Wlodzimierz J Musial
1Department of Cardiology, Medical University, Bialystok, Poland. agnieszka.kuklinska@gmail.com
Objective:
The aim of the study was to evaluate whether measurements of hs-C-reactive protein (hs-CRP), endothelin-1 (ET-1), epinephrine (E) and norepinephrine (NE) would provide useful information for the assessment of endothelial dysfunction and sympathetic nervous system activation in a selected group of young, properly treated patients with essential arterial hypertension (HTN) and without hypercholesterolaemia.
Methods And Results:
Serum hs-CRP and ET-1 as well as plasma epinephrine and norepinephrine concentrations were measured in 134 subjects (62 patients with diagnosed HTN and 72 healthy subjects from a reference group). In patients the concentrations of hs-CRP, ET-1 and NE were significantly higher, than in healthy subjects. The highest diagnostic sensitivity (87%; 95% CI 76.1-94.2) was found for serum hs-CRP; the highest diagnostic specificity (96%; 95% CI 88.3-99.1) and positive predictive value (89%) were found for ET-1 measurements. The analysis of logistic regression showed that the highest risk of HTN was found for the patients with high levels of ET-1, hs-CRP and NE, but not epinephrine.
Conclusions:
These results indicate that measurements of hs-CRP, ET-1 and NE may be useful in the identification of endothelial dysfunction and sympathetic activation in young patients with properly controlled essential arterial hypertension and without hyperlipidaemia.
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