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Serum soluble triggering receptor expressed on myeloid cells-1 in acute respiratory distress syndrome: a prospective

Ming-Tzer Lin1, Yu-Feng Wei, Shih-Chi Ku

  • 1Division of Chest Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei County, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|December 4, 2010
PubMed
Abstract

Insights

Serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is not a reliable infection marker in acute respiratory distress syndrome (ARDS). However, sTREM-1 levels predict mortality, with declining levels indicating a better prognosis.

Area of Science:

  • Critical Care Medicine
  • Immunology
  • Respiratory Medicine

Background:

  • Serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an established marker for acute inflammatory responses.
  • Its role as an infection predictor or prognostic factor in acute respiratory distress syndrome (ARDS) remains uncharacterized.

Purpose of the Study:

  • To investigate the utility of serum sTREM-1 as an infection marker in ARDS.
  • To evaluate sTREM-1 as a prognostic factor for mortality in ARDS patients.

Main Methods:

  • A prospective observational cohort study included 63 ventilated ARDS patients.
  • Serial serum sTREM-1 and cytokine levels (IL-1, IL-8, TNF-α) were measured over 14 days.
  • Statistical analyses explored associations between biomarkers and clinical outcomes.

Main Results:

  • Serum sTREM-1 and cytokine levels did not differentiate septic from non-septic ARDS.
  • Higher initial sTREM-1 levels and increasing trends over the first 5 days independently predicted 28-day mortality.
  • sTREM-1 levels remained elevated in non-survivors and decreased in survivors.

Conclusions:

  • Serum sTREM-1 may not be a reliable marker for infection diagnosis in ARDS.
  • Initial sTREM-1 levels and their dynamic changes are predictive of short-term mortality in ARDS.
  • Monitoring sTREM-1 trends can inform prognosis and guide therapeutic re-evaluation.

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