Role and therapeutic potential of Glycodelin A in systemic lupus erythematosus

Glycodelin A (GdA) is a lipocalin with an immunomodulatory role. Low expression of GdA has been implicated in the progression of autoimmune disease. Therefore, strategies targeting GdA may constitute an important target for the design of drugs for autoimmune disease including systemic lupus erythematosus (SLE). This opinion article will focus on current understanding of the role of GdA in the physiological and pathological functions associated with SLE. It is the intention of the article to provide insights that may assist in the development of GdA-based approaches for the treatment of SLE.