Celiac disease with splenic calcifications

Area of Science:

• Immunology
• Gastroenterology
• Radiology

Background:

• Celiac disease is an immune-mediated enteropathy triggered by gluten sensitivity.
• It presents with diverse gastrointestinal and non-gastrointestinal manifestations.
• Cerebral calcifications are a known, albeit rare, feature in celiac disease (CEC syndrome).

Observation:

• This report details a case of celiac disease in a patient.
• The patient exhibited multiple calcifications within the spleen.
• Crucially, no cerebral calcifications were observed in this individual.

Findings:

• Splenic calcifications are identified as a rare manifestation in celiac disease.
• This finding expands the spectrum of extragastrointestinal manifestations of celiac disease.
• The absence of cerebral calcification in this case differentiates it from the typical CEC syndrome.

Implications:

• Highlights the need to consider splenic calcifications in the differential diagnosis of celiac disease.
• Suggests that calcifications in celiac disease may occur in organs beyond the brain.
• Warrants further investigation into the pathophysiology and prevalence of splenic calcifications in celiac disease.