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Updated: Jun 6, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
G-octamer formation from N⁹ modified guanine derivatives
Jeremy McCallum1, Solomon Amare, Rebecca Nolan
1Department of Chemistry and Biochemistry, Loyola Marymount University, 1 LMU Drive, Los Angeles, CA 90045, USA. jmccallu@lmu.edu
Abstract:
The properties of the self-assembly of two lipophilic guanine derivatives, 2',3',5'-O-tris(tert-butyldimethylsilyl)-guanosine and N⁹-(3,5-bis(tert-butyldimethylsilyloxy)-benzyl)-guanine, are described. In the presence of K+, both guanine derivatives self-associate into D₄-symmetric octamers consisting of two G-quartets stacked around a central ion.
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