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Related Concept Videos

Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
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Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue infection with multi-organ involvement.

Moumita Ghosh1, Mukut Banerjee, Shubhadeep Das

  • 1Department of Paediatric Medicine, Medical College Kolkata, West Bengal, India. dr.moumitaghosh@gmail.com

Scandinavian Journal of Infectious Diseases
|December 7, 2010
PubMed
Summary

Dengue infection can cause severe neurological complications like meningoencephalitis and myelitis. This case highlights a child’s complete recovery from these rare dengue manifestations within three weeks.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Dengue virus infection is a significant global health concern, primarily known for causing febrile illness.
  • Classical dengue symptoms include fever, headache, and body aches, with severe cases presenting hemorrhage and shock.
  • Neurological manifestations of dengue, while documented, are less common than systemic symptoms.

Observation:

  • A 4-year-old child diagnosed with dengue fever presented with acute meningoencephalitis.
  • The child subsequently developed additional severe complications including myelitis, hepatitis, glomerulonephritis, and bone marrow suppression.
  • These complex symptoms indicate a severe systemic response to the dengue virus.

Findings:

  • The pediatric dengue case demonstrated an unusual constellation of neurological and organ-specific complications.
  • Meningoencephalitis, myelitis, hepatitis, glomerulonephritis, and bone marrow suppression were observed in a single dengue patient.
  • The patient experienced a full recovery from all symptoms within a three-week period.

Implications:

  • This case underscores the broad spectrum of potential neurological and systemic complications associated with dengue virus infection in children.
  • Understanding these rare presentations is crucial for early diagnosis and management of severe dengue.
  • The rapid and complete recovery suggests potential for effective therapeutic interventions even in complex cases.