Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 6, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Molecular diagnostics in embryonal brain tumors.

Charles G Eberhart1

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Md 21205, USA. ceberha@jhmi.edu

Brain Pathology (Zurich, Switzerland)
|December 7, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MYC is functionally required in both normal and neoplastic Meibomian glands.

The American journal of pathology·2026
Same author

Case Report: Bilateral optic nerve head masses and retinopathy in a patient with B-cell acute lymphoblastic leukemia receiving CAR T-cell therapy masquerading as fungal endophthalmitis.

Frontiers in immunology·2026
Same author

The dual role of Schlafen11 in brain tumors: Jekyll and Hyde.

Expert review of anticancer therapy·2026
Same author

Stratification by Ki-67 Labeling Index Increases Specificity of p16<sup>INK4a</sup> Expression as a Surrogate Marker for CDKN2A Inactivation in Meningioma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same author

Codelivery Material System of Polymer Microfiber Structures for Synergistic Localized Therapy of Glioblastoma.

ACS biomaterials science & engineering·2026
Same author

LncRNA-HLX-2-7/HLX axis-dependent metabolic reprogramming drives cancer progression in group 3 medulloblastoma.

Acta neuropathologica communications·2026
Same journal

Non-Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions.

Brain pathology (Zurich, Switzerland)·2026
Same journal

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus.

Brain pathology (Zurich, Switzerland)·2026
Same journal

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies.

Brain pathology (Zurich, Switzerland)·2026
Same journal

A 3-year-old girl with a left optic nerve tumor.

Brain pathology (Zurich, Switzerland)·2026
Same journal

Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma.

Brain pathology (Zurich, Switzerland)·2026
Same journal

Nearest-neighbors assisted unsupervised analysis for methylation array profiling for central nervous system tumors.

Brain pathology (Zurich, Switzerland)·2026
See all related articles

Molecular subtyping of embryonal brain tumors, like medulloblastoma and central nervous system Primitive Neuroectodermal Tumors (CNS PNET), aids in classification. Identifying specific molecular variants and genetic alterations improves understanding of tumor biology and patient outcomes.

Area of Science:

  • Neuro-oncology
  • Molecular pathology
  • Pediatric oncology

Background:

  • Embryonal brain tumors are diverse neoplasms characterized by undifferentiated stem-like cells.
  • Molecular profiling is crucial for classifying these tumors into biologically and clinically relevant subgroups.
  • Previous research has identified distinct molecular variants within medulloblastoma and CNS Primitive Neuroectodermal Tumors (CNS PNET).

Purpose of the Study:

  • To review the current understanding of molecular classification in embryonal brain tumors.
  • To highlight key molecular variants within medulloblastoma and CNS PNET.
  • To discuss the clinical implications of these molecular classifications.

Main Methods:

  • Integrated mRNA expression profiling and DNA analysis for medulloblastoma subtyping.

More Related Videos

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Related Experiment Videos

Last Updated: Jun 6, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

  • Identification of gene expression signatures (e.g., Wnt, Hedgehog, MYC).
  • Analysis of chromosomal alterations, such as the 19q13.41-42 amplicon in CNS PNET.

    • Main Results:

    • Medulloblastoma comprises 4-6 molecular variants, including Wnt-active (good prognosis), Hedgehog-associated (desmoplastic/nodular), and MYC-driven (aggressive) subtypes.
    • Immunohistochemical analysis of key genes may suffice for practical classification of medulloblastoma variants.
    • A specific 19q13.41-42 amplicon defines a unique CNS PNET subtype associated with true rosettes, young age, and poor outcomes.

    Conclusions:

    • Molecular subtyping is essential for accurate diagnosis and prognostication of embryonal brain tumors.
    • Further validation of immunohistochemical markers for medulloblastoma classification is warranted.
    • The identification of distinct genetic alterations in CNS PNET offers new avenues for targeted therapies and improved patient management.