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Related Experiment Videos

Renal function after long-term low-dose cyclosporin for psoriasis.

A V Powles1, D Carmichael, B Hulme

  • 1Department of Dermatology, St Mary's Hospital, London.

The British Journal of Dermatology
|May 1, 1990
PubMed
Summary

Cyclosporin A (CyA) can impair kidney function in psoriasis patients, reducing glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). Discontinuing CyA improved GFR, but restarting it caused function to decline again.

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Area of Science:

  • Nephrology
  • Dermatology
  • Pharmacology

Background:

  • Cyclosporin A (CyA) is an immunosuppressant used to treat psoriasis.
  • Long-term effects of CyA on renal function in psoriasis patients require further investigation.

Purpose of the Study:

  • To assess the impact of low-dose Cyclosporin A on renal function in psoriasis patients.
  • To evaluate changes in glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) during CyA treatment and withdrawal.

Main Methods:

  • Two groups of psoriasis patients receiving CyA were studied.
  • Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured.
  • Renal function was assessed before, during, and after CyA treatment periods.

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Main Results:

  • In patients on long-term low-dose CyA, six out of 13 showed reduced GFR, which improved upon CyA discontinuation but declined again upon restarting.
  • In a second group, GFR and ERPF significantly decreased after a mean of 9 weeks of CyA treatment.
  • Eight out of 11 patients experienced a drop in GFR, and seven out of nine showed a decrease in ERPF.

Conclusions:

  • Low-dose Cyclosporin A can negatively affect renal function in psoriasis patients.
  • Reversible declines in GFR and ERPF are associated with CyA use.
  • Monitoring renal function is crucial for patients with psoriasis treated with CyA.