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Updated: Jun 6, 2026

Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
[Hybrid renal tumors: a report of two patients]
N B Delongchamps1, A Vieillefond, M Peyromaure
1Service d'urologie, hôpital Cochin, université Paris-Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
Purpose:
Renal hybrid tumors (HT) are characterized by the association of both oncocytes- and chromophobe-cells within the same tumor. They have been reported in patients with Birt-Hogg-Dube (BHD) syndrome. The aim of this report was to describe two cases of HT and summarize recent literature.
Patient And Method:
Case study was summarized from the patient's medical chart. Review of literature was performed using the National Center for Biotechnology Information (NCBI) database.
Results:
Two patients were diagnosed with multiple but small tumors of the kidney, and were treated with partial nephrectomy. Pathological analysis of these tumors showed oncocytoma-like and chromophobe-like cells intermixed in the same stroma.
Conclusions:
HT may constitute a spectrum of tumors between renal oncocytoma and chromophobe renal cell carcinoma. From a pragmatic management perspective, it would be appropriate to consider such tumors as chromophobe carcinoma. In case of HT, a genetic study for BHD syndrome can be proposed to family relatives.
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