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Related Experiment Video

Updated: Jun 6, 2026

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach
07:16

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

Published on: April 25, 2025

A novel repeat biopsy nomogram based on three-dimensional extended biopsy.

Mizuaki Sakura1, Satoru Kawakami, Junichiro Ishioka

  • 1Department of Urology, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan.

Urology
|December 7, 2010
PubMed
Summary

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A new prostate cancer nomogram aids repeat biopsies. This tool helps avoid unnecessary procedures by accurately identifying men who do not require further biopsies, improving patient care.

Area of Science:

  • Urologic Oncology
  • Diagnostic Imaging
  • Biostatistics

Background:

  • Repeat prostate biopsies are often necessary due to inconclusive initial results.
  • Accurate risk stratification is crucial to minimize unnecessary invasive procedures.
  • Three-dimensional (3D) imaging protocols offer detailed anatomical information for diagnosis.

Purpose of the Study:

  • To develop and validate a predictive nomogram for prostate cancer diagnosis in men undergoing repeat biopsy.
  • To utilize a cohort examined with a 3D protocol for nomogram development.
  • To assess the clinical utility of the nomogram in reducing unnecessary biopsies.

Main Methods:

  • A cohort of 515 men with previous negative biopsies undergoing repeat biopsy with a 3D protocol was analyzed.

Related Experiment Videos

Last Updated: Jun 6, 2026

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach
07:16

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

Published on: April 25, 2025

  • A logistic regression model was used to develop a nomogram incorporating clinical and biomarker data.
  • The nomogram was validated on 30% of the cohort using area under the receiver operating characteristic curve (AUC) and calibration plots.

    • Main Results:

    • A novel repeat biopsy nomogram was developed, incorporating age, free to total prostate-specific antigen (PSA) ratio, prostate volume, prior biopsy history, and PSA doubling time.
    • The nomogram demonstrated good predictive accuracy with an AUC of 0.791.
    • Decision curve analysis showed the nomogram outperformed universal biopsy strategies, potentially reducing unnecessary biopsies by 10% without missing cancers at a threshold of 0.2.

    Conclusions:

    • A novel, clinically beneficial nomogram for repeat prostate biopsy diagnosis was developed using a 3D protocol cohort.
    • The nomogram effectively aids in identifying men who can avoid unnecessary repeat biopsies.
    • This tool has the potential to significantly improve patient management and reduce healthcare costs associated with repeat prostate biopsies.