Related Experiment Video
Updated: Jun 6, 2026
08:54
An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
Etiological difference between ultrashort- and short-segment Barrett's esophagus.
Juntaro Matsuzaki1, Hidekazu Suzuki, Keiko Asakura
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Journal of Gastroenterology
|December 7, 2010
Summary
Gastric corpus atrophy is linked to ultrashort-segment Barrett's esophagus (USBE), while gallstones are associated with short-segment Barrett's esophagus (SSBE). This suggests different causes for these conditions.
Area of Science:
- Gastroenterology
- Esophageal Diseases
- Oncology
Background:
- Barrett's esophagus is classified by metaplasia extent: long-segment (LSBE), short-segment (SSBE), and ultrashort-segment (USBE).
- LSBE and SSBE are linked to gastroesophageal reflux, but USBE etiology remains unclear.
Purpose of the Study:
- To investigate the distinct pathogenic mechanisms differentiating SSBE and USBE.
- To compare endoscopic and clinical factors in patients with SSBE and USBE.
Main Methods:
- A case-control study was performed.
- Compared 199 patients with short-segment ESEM (SS-ESEM) and 317 with US-ESEM against matched controls without ESEM.
Main Results:
- Gastric mucosal atrophy showed a marginal association with US-ESEM (OR 1.20), but not SS-ESEM.
- Gallstones and severe reflux esophagitis were associated with SS-ESEM (OR 2.19 and 1.72, respectively), but not US-ESEM.
- Gastric corpus atrophy without gallstones was linked to US-ESEM, not SS-ESEM.
Conclusions:
- Gastric corpus atrophy is associated with increased likelihood of US-ESEM.
- Gallstones are associated with increased likelihood of SS-ESEM.
- Findings suggest differing etiologies between US- and SS-ESEM.
Related Concept Videos
01:21Barrett Esophagus-I: Introduction
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
01:21Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
01:30Esophageal Strictures-I: Introduction
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
01:24Esophageal Varices-I: Introduction
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
01:26Esophageal Strictures-II: Clinical Features and Management
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
01:30Peptic Ulcer Disease I: Introduction
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...