Obstructive airway disease and obstructive sleep apnea: effect of pulmonary function
Bhavneesh Sharma1, Steven Feinsilver, Robert L Owens
1Division of Sleep Medicine, Harvard Medical School/Brigham and Women's Hospital, Boston, MA 02115, USA. bksharma@partners.org
Lung
|December 7, 2010
Summary
Reduced pulmonary function is not an independent risk factor for obstructive sleep apnea (OSA) in patients with obstructive airway disease (OAD). Obesity, not lung function, drives the higher prevalence of OSA in OAD patients.
Area of Science:
- Pulmonary Medicine
- Sleep Medicine
- Respiratory Research
Background:
- Obstructive airway disease (OAD), including COPD and asthma, is prevalent. Obstructive sleep apnea (OSA) is a common sleep disorder.
- The relationship between reduced pulmonary function in OAD and the risk of developing OSA requires clarification.
Purpose of the Study:
- To investigate if reduced pulmonary function, measured by FEV(1) % predicted, is an independent risk factor for OSA in patients with OAD.
- To determine the prevalence of high OSA risk in an OAD population compared to a control group.
Main Methods:
- Prospective observational study in an outpatient pulmonary clinic.
- Berlin Questionnaire (BQ) for OSA risk assessment, spirometry for FEV(1) % predicted, and polysomnography (PSG) for high-risk individuals.
- Comparison of OAD patients (COPD/asthma) with a control group of family members.
Main Results:
- The prevalence of high OSA risk was significantly higher in the OAD group (55.2%) than in controls (7.5%, p < 0.0001).
- OAD patients with high OSA risk had higher BMI and neck circumference, suggesting obesity as a factor.
- FEV(1) % predicted did not predict OSA risk and showed no association or correlation with OSA severity metrics (AHI, oxygen desaturation).
Conclusions:
- OSA is common in patients with COPD or asthma.
- Obesity, not reduced pulmonary function, appears to be the primary driver for the increased OSA prevalence in OAD patients.
- Reduced pulmonary function is not an independent risk factor for OSA in this population.
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