Related Experiment Video

Updated: Jun 6, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Clinical practice guidelines: what they are, why we need them and how they should be developed through rigorous

Cristina Cecamore1, Alessandra Savino, Roberta Salvatore

  • 1University Department of Paediatrics, Ospedale Policlinico, Chieti, Italy.

European Journal of Pediatrics
|December 7, 2010
PubMed

Insights

This review clarifies clinical practice guidelines, covering their development, evaluation, and application. It emphasizes rigorous scientific methods for creating and assessing these essential healthcare tools, including pediatric guidelines.

Area of Science:

  • Health Sciences
  • Medical Research
  • Evidence-Based Practice

Background:

  • The proliferation of clinical practice guidelines necessitates standardized approaches for their effective utilization.
  • Understanding the development, evaluation, and application of guidelines is crucial for healthcare professionals.

Purpose of the Study:

  • To provide a comprehensive revision of clinical practice guidelines.
  • To outline methods for developing, finding, and evaluating guidelines using scientific rigor.
  • To discuss the benefits and limitations of guidelines, with a focus on pediatric applications.

Main Methods:

  • Systematic literature review and synthesis of existing research on guideline development and evaluation.
  • Analysis of methodologies for guideline creation and assessment.
  • Discussion of evidence-based approaches in guideline implementation.

Main Results:

  • Established frameworks for guideline development and evaluation.
  • Identified key benefits and limitations associated with guideline use.
  • Provided an overview of the specific considerations for pediatric clinical practice guidelines.

Conclusions:

  • Effective utilization of clinical practice guidelines requires a thorough understanding of their development and evaluation.
  • Rigorous scientific methods are essential for creating high-quality, reliable guidelines.
  • Guidelines, particularly in pediatrics, offer significant benefits when developed and applied correctly.

Related Concept Videos

Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care evaluation by...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Good Manufacturing Practices01:26

Good Manufacturing Practices

Good Manufacturing Practices (GMP) constitute a foundational set of guidelines that ensure the production of safe, consistent, and high-quality products, particularly in industries such as pharmaceuticals, biotechnology, and food processing. These protocols encompass all aspects of production, from the sourcing of raw materials to the final distribution of the finished product.A core pillar of GMP is stringent hygiene and sanitation across all production environments. This includes routine...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Nursing Interventions II: Selecting and Classifying the Nursing Interventions01:29

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions: