[Kidney biopsy in Mantua: 2000-2009 report]

Area of Science:

• Nephrology
• Pathology
• Epidemiology

Context:

• Kidney diseases represent a significant global health burden.
• Understanding the epidemiological and histological characteristics of renal diseases is crucial for effective clinical management.
• Data from specific geographic regions, like Mantua province, contribute to a broader understanding of kidney disease prevalence.

Purpose:

• To determine the frequency of kidney diseases based on gender, age, clinical presentation, and renal function.
• To analyze histological findings from 132 kidney biopsies performed in Mantua province.
• To compare findings with existing Italian and European renal disease registries.

Summary:

• The study analyzed 132 kidney biopsies, with nephrotic syndrome (57%) and nephritic syndrome (22%) as primary clinical presentations.
• Membranous nephropathy (21.4%) and IgA nephropathy (14.5%) were the most frequent histological diagnoses.
• Primary glomerulonephritis, including membranous and IgA nephropathy, exhibited a male predominance.

Impact:

• Provides valuable pathological correlations for native biopsy-proven renal diseases, aiding clinical practice.
• Findings are comparable to Italian and European registries, offering regional insights.
• Suggests a less invasive approach for isolated urinary abnormalities with normal estimated glomerular filtration rate (eGFR) may reduce IgA nephropathy incidence.