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Published on: September 20, 2011
Tablets containing drug-loaded polymeric nanocapsules: an innovative platform
R B Friedrich1, M O Bastos, M C Fontana
1Programa de Pós-Graduagĩo em Ciências Farmacêuticas, Departamento de Farmácia Industrial, Av. Roraima, 1000, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
Journal of Nanoscience and Nanotechnology
|December 8, 2010
Summary
This study demonstrates the successful conversion of dexamethasone-loaded nanocapsule suspensions into solid tablets. The novel nanocapsule tablets offer a slower drug release profile compared to conventional formulations.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Dexamethasone exhibits low aqueous solubility and rapid release from conventional tablets.
- Developing solid dosage forms for poorly soluble drugs requires advanced delivery systems.
- Nanocapsules offer potential for controlled drug release and improved bioavailability.
Purpose of the Study:
- To assess the feasibility of formulating drug-loaded nanocapsules into solid tablets.
- To characterize the physicochemical properties and in vitro drug release of the novel tablet formulation.
- To evaluate nanocapsule integrity within the solid dosage form.
Main Methods:
- Wet granulation using a polyvinylpyrrolidone/nanocapsule dispersion as a binder.
- Tablet compression using an eccentric compression machine.
- Comprehensive tablet characterization: physicochemical tests, SEM imaging, and in vitro drug release studies.
Main Results:
- Tablets containing dexamethasone-loaded nanocapsules (D-NC-T) met pharmacopeial standards for physicochemical properties.
- Scanning electron microscopy confirmed the presence of intact nanocapsules within the tablet matrix.
- In vitro studies revealed a significantly slower dexamethasone release from D-NC-T compared to control tablets (D-T).
Conclusions:
- Solid tablets incorporating polymeric nanocapsules are a feasible oral drug delivery platform.
- This formulation strategy can modulate drug release kinetics for poorly soluble drugs like dexamethasone.
- The developed tablets represent a promising approach for advanced oral drug delivery systems.
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