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Related Experiment Video

Updated: Jun 6, 2026

The Microfluidic Probe: Operation and Use for Localized Surface Processing
08:07

The Microfluidic Probe: Operation and Use for Localized Surface Processing

Published on: June 4, 2009

Integrated microfluidic probe station.

C M Perrault1, M A Qasaimeh, T Brastaviceanu

  • 1Department of Biomedical Engineering, McGill University, Montréal, Quebec, H3A 1A4, Canada.

The Review of Scientific Instruments
|December 8, 2010
PubMed
Summary
This summary is machine-generated.

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A new automated microfluidic probe (MFP) station enables precise, live-imaged surface processing. This system enhances control over microjetting for reproducible material deposition and removal, even on sensitive biological samples.

Area of Science:

  • Microfluidics
  • Surface Science
  • Biotechnology

Background:

  • Microfluidic probes (MFPs) enable precise surface manipulation via microjets.
  • Live imaging is crucial for monitoring surface processing.
  • Current MFP operation requires manual control of critical parameters, limiting reproducibility.

Purpose of the Study:

  • To develop and present an automated microfluidic probe station.
  • To integrate and synchronize key operational parameters for consistent surface processing.
  • To demonstrate automated patterning capabilities using the integrated system.

Main Methods:

  • An automated MFP station was developed, integrating a motorized Z stage, motorized microscope stage, and multiple syringe pumps.
  • A custom software program controlled fluidics, scanning, and imaging synchronization.

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A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device
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A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device

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Last Updated: Jun 6, 2026

The Microfluidic Probe: Operation and Use for Localized Surface Processing
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Published on: June 4, 2009

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
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  • Manual goniometer and a novel MFP screw holder were used for initial alignment and parallelism adjustment.

    • Main Results:

    • The automated station successfully integrated control of gap, scanning, flow rates, and image capture.
    • Automated, programmed patterning of fluorescently labeled biotin on a streptavidin-coated surface was demonstrated.
    • The system offers enhanced control for reproducible microfluidic surface processing.

    Conclusions:

    • The automated MFP station provides a robust platform for precise and reproducible surface modification.
    • This system is suitable for processing sensitive biological materials and living cells under live imaging.
    • The automated patterning capability opens new avenues for microfluidic applications in research and development.