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Updated: Jun 6, 2026
07:07
A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
[Melanoma in HIV patients: 14 cases]
S Qasmi1, C Sutra-Loubet, E Maubec
1Service de Dermatologie, Université Paris 5, Hôpital Cochin-pavillon Tornier, 89, rue d'Assas, AP-HP, 75006 Paris, France.
Annales De Dermatologie Et De Venereologie
|December 8, 2010
Summary
The presence of human immunodeficiency virus (HIV) appears to worsen outcomes for patients with malignant melanoma. Early detection of melanoma in HIV-infected individuals is crucial for better management.
Area of Science:
- Oncology
- Infectious Diseases
- Dermatology
Context:
- Investigates the association between malignant melanoma and human immunodeficiency virus (HIV) infection.
- Analyzes clinical data from 14 patients with both conditions.
- Reviews existing literature to understand the frequency and characteristics of this comorbidity.
Purpose:
- To determine the frequency and specific features of the association between malignant melanoma and HIV infection.
- To evaluate the impact of HIV infection on the prognosis of malignant melanoma.
Summary:
- A study of 14 patients (10 men, 4 women; median age 43) with malignant melanoma and HIV infection.
- Melanoma characteristics included superficial spreading type (50%) with a mean Breslow thickness of 2.83 mm; lymph node metastasis occurred in two cases without a primary melanoma identified.
- HIV was diagnosed before melanoma in 11 cases and at melanoma diagnosis/surgery in three cases. Six of eight deaths were melanoma-related, with a poor prognosis (mean stage IV survival 3.6 months) and no response to chemotherapy.
Impact:
- HIV infection is identified as an aggravating factor for metastatic melanoma outcomes.
- Highlights the importance of thorough clinical examination of pigmented lesions in HIV-positive patients for early melanoma detection.
- Suggests a need for heightened vigilance and potentially tailored management strategies for melanoma in the context of HIV infection.
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