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[Superficial acral fibromyxoma: three cases]
O Cogrel1, S Stanislas, J-M Coindre
1Service de Dermatologie, Hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac Cedex, France. olivier.cogrel@chu-bordeaux.fr
Annales De Dermatologie Et De Venereologie
|December 8, 2010
Summary
Superficial acral fibromyxoma (SAF) presents as a common yet underrecognized extremity tumor. Histopathology can mimic other conditions, necessitating careful diagnosis to distinguish it from more aggressive tumors.
Area of Science:
- Dermatopathology
- Oncology
- Surgical Pathology
Background:
- Superficial acral fibromyxoma (SAF) is an underrecognized fibrous tumor of the extremities.
- This report details three new cases, focusing on clinicopathological features and differential diagnoses for extremity nodules.
Observation:
- Lesions presented as solitary, flesh-colored nodules on digits, causing nail deformation.
- Biopsies revealed fibromyxoid tumors with proliferating fusiform cells lacking atypia.
Findings:
- Immunohistochemistry showed diffuse CD 34 expression, with focal EMA and CD 99 positivity.
- Fluorescence in situ hybridization (FISH) for translocation t(17; 22) was negative in all cases.
Implications:
- Accurate histological differentiation is crucial, as SAF can be mistaken for myxoid dermatofibrosarcoma.
- Understanding SAF's features aids in correct diagnosis and appropriate patient management, avoiding unnecessary aggressive treatment.
