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Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
Published on: March 25, 2022
Primary biliary cirrhosis in Brunei Darussalam
Vui Heng Chong1, Pemasiri Upali Telisinghe, Anand Jalihal
1Gastroenterology and Hepatology Unit, Department of Medicine, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan BA 1710, Brunei Darussalam. chongvuih@yahoo.co.uk
Hepatobiliary & Pancreatic Diseases International : HBPD INT
|December 8, 2010
Summary
Primary biliary cirrhosis (PBC) predominantly affects women in Brunei, with higher prevalence in Chinese and indigenous populations. PBC patients showed distinct human leukocyte antigen (HLA) class I profiles compared to controls.
Area of Science:
- Hepatology
- Immunogenetics
- Autoimmune Diseases
Background:
- Primary biliary cirrhosis (PBC) is a rare autoimmune liver disease primarily affecting women.
- Human leukocyte antigen (HLA) associations are known for PBC susceptibility.
- This study characterizes PBC in Brunei Darussalam.
Purpose of the Study:
- To describe the clinical and demographic profiles of PBC patients in Brunei.
- To investigate the association of HLA alleles with PBC in this population.
- To compare PBC profiles with autoimmune hepatitis (AIH).
Main Methods:
- Retrospective analysis of 10 PBC patients.
- Comparison of HLA profiles (9 PBC patients) with 65 controls and 13 AIH patients.
- Review of clinical data, symptoms, serology, and liver biopsies.
Main Results:
- All PBC patients were women; median age at diagnosis was 51 years.
- Prevalence was 25.6/million, higher in Chinese and indigenous groups.
- PBC patients showed increased HLA class I alleles (B7, Cw7, Cw12) versus controls; no difference with AIH.
Conclusions:
- PBC is a female-predominant disorder in Brunei with generally mild disease.
- The HLA profile in Brunei PBC patients differs from previously reported findings.
- Further research into HLA associations in diverse populations is warranted.
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