Related Experiment Videos
Peritonitis in myelofibrosis: a cautionary tale
Narasimhaiah Srinivasaiah1, Mohammad K Zia, Vummiti Muralikrishnan
1Department of General Surgery, Princess of Wales Hospital, City Road, Bridgend CF31 1RQ, UK. simha_anu@yahoo.com
Background:
Primary myelofibrosis (PMF) is a myeloproliferative disorder characterized by bone marrow fibrosis. Extra-medullary hematopoiesis sometimes occurs even in the peritoneal cavity, apart from organs such as the liver, spleen, and lymph nodes. This may sometimes be complicated by spontaneous infection and complications. We report a rather unusual case of PMF, who presented as an emergency with spontaneous peritonitis to general surgery department and had a fulminant clinical course.
Method:
A clinical case note review was done and a literature search was undertaken.
Results:
A rather unusual case of PMF, who presented as an emergency with spontaneous peritonitis to general surgery department. The patient underwent a laparotomy and had a fulminant clinical course.
Conclusions:
Peritonitis in myelofibrosis may have a number of causes. Clinicians need to be aware of them and provide conservative management prior to surgical treatment.
Insights
Primary myelofibrosis can cause spontaneous peritonitis, a rare but serious complication. Early recognition and conservative management are crucial for patients presenting with this condition.
Area of Science:
- Hematology
- Gastroenterology
Background:
- Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by bone marrow fibrosis.
- Extramedullary hematopoiesis in PMF can occur in unusual locations, including the peritoneal cavity.
- Complications such as spontaneous infection can arise from extramedullary hematopoiesis.
Observation:
- A case of PMF presented with spontaneous peritonitis requiring emergency surgical evaluation.
- The patient experienced a rapid and severe clinical course.
Findings:
- Spontaneous peritonitis is a rare but significant complication in primary myelofibrosis.
- The clinical presentation can be fulminant, necessitating prompt diagnosis.
Implications:
- Clinicians must consider peritonitis in PMF patients, recognizing diverse etiologies.
- Conservative management strategies should be prioritized before surgical intervention.
- Awareness of this complication can improve patient outcomes in primary myelofibrosis.
Related Concept Videos
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:28Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
01:19Appendicitis
01:22Pericarditis I: Introduction