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Fibroblast growth factor 23 in chronic kidney disease: bridging the gap between bone mineral metabolism and left

M E F Canziani1, C Tomiyama, A Higa

  • 1Nephrology Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil. dialisefor@uol.com.br

Blood Purification
|December 8, 2010
PubMed

Insights

Left ventricular hypertrophy (LVH) is common in chronic kidney disease (CKD). Fibroblast growth factor 23 (FGF23) is a key factor associated with LVH in nondialyzed CKD patients, suggesting monitoring FGF23 may aid management.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Left ventricular hypertrophy (LVH) is a significant cardiovascular complication in patients with chronic kidney disease (CKD).
  • Understanding factors contributing to LVH is crucial for effective management in CKD.
  • Bone mineral metabolism is increasingly recognized as a factor in CKD complications.

Purpose of the Study:

  • To investigate the association between bone mineral metabolism markers and LVH in nondialyzed CKD patients.
  • To identify clinical correlates of LVH in stages 2-4 CKD.
  • To explore the role of emerging factors like FGF23 in LVH development.

Main Methods:

  • Cross-sectional study of 96 patients with stages 2-4 CKD.
  • Data collection included demographic, clinical, laboratory, and echocardiographic parameters.
  • Analysis focused on identifying associations between bone mineral metabolism markers and LVH.

Main Results:

  • LVH prevalence was 36% among the studied CKD patients.
  • Patients with LVH were older, had more hypertension, and higher intact parathormone, FGF23, and C-reactive protein levels.
  • Fibroblast growth factor 23 (FGF23) was the only variable independently associated with LVH in multivariate analysis.

Conclusions:

  • LVH is highly prevalent in nondialyzed CKD patients.
  • FGF23, an early indicator of phosphorus load, is significantly associated with LVH in this population.
  • Monitoring FGF23 levels may be important for managing LVH in CKD patients.
Abstract

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