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Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
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Human pathogenic streptococcal proteomics and vaccine development.

Jason N Cole1, Anna Henningham, Christine M Gillen

  • 1School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia.

Proteomics. Clinical Applications
|December 8, 2010
PubMed
Summary
This summary is machine-generated.

This review explores streptococcal cell wall and secreted proteins. It highlights how proteomics and genomics identify novel vaccine candidates and therapeutic targets from these bacteria.

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Last Updated: Jun 6, 2026

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
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Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
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Published on: December 19, 2020

Area of Science:

  • Microbiology
  • Proteomics
  • Genomics

Background:

  • Gram-positive streptococci are common bacteria in animal flora.
  • Proteomic techniques like 2-DE and MS have mapped streptococcal proteins.
  • Genomic data aids in discovering new vaccine and therapeutic targets.

Purpose of the Study:

  • To review streptococcal cell wall and secreted proteomes.
  • To examine protein transport mechanisms in streptococci.
  • To describe methods for identifying novel surface proteins and vaccine antigens.

Main Methods:

  • Proteomic analysis (2-DE, MS) of streptococcal proteins.
  • Genomic sequencing and bioinformatic integration.
  • Methodologies for identifying surface-displayed proteins.

Main Results:

  • Systematic mapping of cellular, surface-associated, and secreted proteins.
  • Identification of potential vaccine candidate antigens.
  • Discovery of novel therapeutic agents.

Conclusions:

  • Proteomic and genomic approaches are powerful for streptococcal research.
  • Understanding protein localization and transport is crucial.
  • This research facilitates the development of new streptococcal vaccines and therapies.