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Updated: Jun 6, 2026
08:46
Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
Published on: May 18, 2016
Sporotrichosis: Part II
1Instituto de Dermatologia Prof Rubem David Azulay (IDPRDA), Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil. regina.schechtman@gmail.com
Skinmed
|December 9, 2010
Summary
Sporotrichosis diagnosis relies on culturing Sporothrix schenckii, as other methods are unreliable. Antifungal treatments like itraconazole and terbinafine show promise for this subcutaneous mycosis.
Area of Science:
- Mycology
- Infectious Diseases
- Dermatology
Background:
- Sporotrichosis is a subcutaneous fungal infection caused by Sporothrix schenckii.
- Diagnosis is challenging due to the low yield of direct examination and histology.
- Culture isolation of Sporothrix schenckii is the gold standard for diagnosis.
Purpose of the Study:
- To review the diagnostic challenges and treatment options for sporotrichosis.
- To investigate the epidemiology and antifungal susceptibility of Sporothrix schenckii strains involved in an outbreak in Brazil.
- To understand the genetic relatedness of Sporothrix schenckii isolates.
Main Methods:
- Review of diagnostic methods for sporotrichosis.
- Analysis of epidemiological data from a Brazilian outbreak.
- Molecular diagnosis and antifungal susceptibility testing of Sporothrix schenckii strains.
- Genetic characterization of isolated strains.
Main Results:
- Direct examination and histology are of limited value for sporotrichosis diagnosis.
- Culture is essential for identifying Sporothrix schenckii.
- Potassium iodide, itraconazole, and terbinafine are discussed as therapeutic options.
- Feline transmission was linked to a significant sporotrichosis outbreak in Rio de Janeiro.
- Isolated Sporothrix schenckii strains were genetically related, suggesting a common source or transmission event.
Conclusions:
- Accurate diagnosis of sporotrichosis depends on fungal culture.
- Itraconazole and terbinafine are potential therapeutic alternatives.
- Molecular studies are crucial for understanding sporotrichosis outbreaks and strain characteristics.
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