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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jun 6, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Multifunctional nanoparticles for targeting cancer therapy.

Zhong-Gao Gao¹, Zhe-Hu Jin, Xue-Zhe Yin

¹Institute of Materia Medico, Chinese Academy of Medical Sciences, Beijing 100050, China.

Journal of Nanoscience and Nanotechnology

|December 9, 2010

Summary

Dual functional nanoparticles carrying chemotherapy drugs and MRI agents were developed. These nanoparticles effectively target tumors, inhibit growth, and enable simultaneous chemotherapy and MRI imaging in vivo.

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Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Developing targeted drug delivery systems is crucial for effective cancer therapy.
Simultaneous imaging and treatment can improve therapeutic outcomes and reduce side effects.

Purpose of the Study:

To create dual functional nanoparticles for combined chemotherapy and MRI imaging.
To evaluate the efficacy of these nanoparticles in targeting tumors and inhibiting cancer growth in vivo.

Main Methods:

Encapsulation of Doxorubicin (chemotherapy drug) and Iron Oxide (MRI agent) into PEG-Folate acid nanoparticles.
Characterization of nanoparticle size (approx. 45 nm) and monodispersity using a zeta-sizer.
In vivo administration via rabbit ear vein and assessment of liver image contrast enhancement.
Evaluation of tumor targeting and growth inhibition in a subcutaneous A2780 Ovarian cancer model.

Main Results:

Nanoparticles demonstrated enhanced liver image contrast post-injection.
PEG-FA coated nanoparticles selectively targeted tumor sites.
Effective inhibition of tumor growth was observed in vivo.
Successful simultaneous chemotherapy and MRI imaging was achieved.

Conclusions:

Dual functional nanoparticles offer a promising platform for targeted cancer therapy.
The developed nanoparticles enable simultaneous chemotherapy and MRI imaging for enhanced cancer treatment.
This approach holds potential for improving in vivo cancer treatment strategies.