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[The expressional alterations of CSF-1R after ischemic injury of cerebral cortex]
Dong Hui Yu1, Shuang Liu, Zeng-Min Tian
1Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
Aim:
To observe the expressional alterations of colony stimulating factor-1 receptor (CSF-1R) after ischemic injury of cerebral cortex, and study the function of colony stimulating factor-1 (CSF-1)/CSF-1R signal during the process of ischemic injury and repair of central nervous system (CNS).
Methods:
We examined the distribution and expression of CSF-1R in normal brain tissues and ischemic brain tissues by immunohistology and Western blot analysis.
Results:
The expression of CSF-1R in neurons could be up-regulated by ischemic injury in CNS.
Conclusion:
CSF-1/CSF-1R might take part in the process of ischemic injury and repair.
