Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).

Modeling in Therapy

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in situations...

Methods of Documentation VI: Case Management Model

Methods of Documentation VI: Case Management Model

The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic illness...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Pharmacodynamic Models: Overview

Pharmacodynamic Models: Overview

Pharmacodynamic (PD) responses describe the interaction between a drug and its biological target, culminating in a physiological effect. These responses can be classified into different types: continuous variables, such as blood glucose levels; categorical outcomes, like survival rates; and time-to-event metrics, such as disease progression. Understanding and modeling PD responses are critical for optimizing drug efficacy and safety.PD models describe the relationship between drug concentration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Increased grain weight conferred by GW2 mutations in wheat does not translate into yield gains in multi-year field trials of near-isogenic lines.

Journal of experimental botany·2026

Same author

Embedding Multiperspective Reflections in Co-Producing a Training Intervention for Care Home Staff: Understanding Group Members' Journeys and Impacts.

Health expectations : an international journal of public participation in health care and health policy·2026

Same author

Remote multidisciplinary diagnostic discussion and spirometry for ILD patients in rural Virginia.

BMC pulmonary medicine·2025

Same author

Key action areas for transforming the UK food system: insights from the Transforming UK Food Systems (TUKFS) Programme project portfolio.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2025

Same author

Measuring the socio-economic and environmental outcomes of regenerative agriculture across spatio-temporal scales.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2025

Same author

Family-Based Strategies for Healthy Screen Use and the Role of Motivational Interviewing.

Journal of the American Academy of Child and Adolescent Psychiatry·2025

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

A psoriasis-specific model to support decision making in practice - UK experience.

Keith Freeman¹, Maggie Marum, Julia M Bottomley

¹County Durham and Darlington NHS Foundation Trust & Sunderland Teaching Primary Care Trust, Sunderland, UK.

Current Medical Research and Opinion

|December 15, 2010

Summary

Developing an interactive psoriasis model can optimize treatment strategies and reduce healthcare costs. This tool helps compare topical treatments for moderate psoriasis, potentially saving millions in the UK.

More Related Videos

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Related Experiment Videos

Last Updated: Jun 6, 2026

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Health Economics
Health Services Research

Background:

Service provision for psoriasis patients is often imbalanced between community and hospital settings.
Disease-specific models are crucial for public health decision-making and budget allocation.
Current treatment strategies for moderate psoriasis require evaluation in real-world settings.

Purpose of the Study:

To develop an interactive psoriasis model.
To compare the 2-year outcomes of topical treatment strategies for moderate psoriasis.
To assess cost-effectiveness in real-world settings.

Main Methods:

Adaptation of a 1-year economic analysis of calcipotriol/betamethasone dipropionate (TCF) and other topical agents.
Literature review and interviews to gather data for model assumptions.
Estimation of local psoriasis costs and resources, with adaptable input data for local circumstances.

Main Results:

High-efficacy first-line topical therapies are cost-effective for moderate plaque psoriasis.
The model predicts potential UK savings of £126 million over 2 years with TCF in community settings.
The model identifies methods to reduce inappropriate hospital referrals, focusing secondary care on severe cases.

Conclusions:

The psoriasis disease model can enhance collaboration among healthcare professionals for optimized UK healthcare.
It allows comparison of primary care management strategies in realistic settings to identify optimal regimens.
The adaptable model serves as a valuable tool for GP commissioners, with international adaptations underway.