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Updated: Jun 6, 2026
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Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
Published on: June 3, 2021
Evaluation of cerebral hemorrhage volume using transcranial color-coded duplex sonography
Noriko Matsumoto1, Kazumi Kimura, Yasuyuki Iguchi
1Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan. noripma@med.kawasaki-m.ac.jp
Summary
Transcranial color-coded duplex sonography (TCCS) accurately measures hematoma volume in patients with intracranial hemorrhage. This non-invasive ultrasound technique shows good correlation and agreement with computed tomography (CT) for volume estimation.
Area of Science:
- Neurology
- Medical Imaging
- Ultrasound Technology
Background:
- Transcranial color-coded duplex sonography (TCCS) is established for assessing cerebral structures.
- Accurate measurement of intracranial hematoma volume is crucial for patient management.
Purpose of the Study:
- To evaluate the utility of TCCS in determining hematoma volume.
- To compare TCCS measurements with computed tomography (CT) findings.
Main Methods:
- Patients with acute supratentorial intracranial hemorrhage were enrolled.
- Hematoma dimensions (longitudinal, sagittal, coronal) were measured using both CT and TCCS.
- Hematoma volume was calculated using the formula V = longitudinal × sagittal × coronal/2.
Main Results:
- A strong correlation was observed between TCCS and CT for all measured diameters and estimated hematoma volume (r values ranging from .595 to .907, P < .0001).
- The Bland-Altman analysis indicated good agreement between the two imaging modalities, with a mean difference of 0.31.
- The study included 20 patients with suitable temporal windows for TCCS examination.
Conclusions:
- TCCS demonstrates significant utility as a method for evaluating intracranial hematoma volume.
- The findings suggest TCCS can be a reliable alternative or complementary tool to CT for hematoma volume assessment.
