Synchronous multicentric osteosarcoma involving mandible and maxillas

Area of Science:

• Oncology
• Oral and Maxillofacial Surgery
• Pathology

Background:

• Synchronous multicentric osteosarcoma (SMO) is exceptionally rare, with limited documented cases.
• SMO involving the jaw is particularly uncommon, with only three prior reports focusing on the mandible.
• No previous cases of SMO originating in the maxilla have been documented.

Observation:

• The authors present the first case of SMO affecting both the mandible and maxilla.
• The patient was an 18-year-old female.
• Clinical, radiological, and histological findings were consistent with SMO, distinguishing it from metastatic disease.

Findings:

• This case represents the first documented instance of synchronous multicentric osteosarcoma involving both the maxilla and mandible.
• The findings support the multicentric theory of SMO development.
• The distinct presentation in both upper and lower jaws offers new insights into SMO's potential origins.

Implications:

• This case expands the understanding of SMO presentation and location.
• It provides critical evidence for the multicentric theory of SMO.
• Further research into the etiology of multicentric bone cancers is warranted.