Related Experiment Video
Updated: Aug 18, 2026

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia
Published on: June 22, 2013
[The hemostasis system in hypoxic anoxia of varying degree]
Abstract:
This paper presents an overview of investigations of blood coagulation of man exposed to hypoxic hypoxia or hypoxia combined with hypercapnia. Blood coagulation changes were related to the level of hypoxia and correlated with variations in blood gases and acid-base characteristics. Prognostic criteria associated with increased coagulation in response to hypoxia were formulated. It was found that hypoxia of any degree reduced significantly the stimulation effect of epinephrine on blood coagulation and fibrinolysis. The paper discusses the relationship between respiratory and hemostatic functions of blood and mechanisms regulating its aggregation during hypoxia of various degree. It is recommended to add carbon dioxide in moderate concentrations to the hypoxic environment in order to prevent blood hypercoagulation and to increase its resistance to acute hypoxia and epinephrine-induced lesions. It is concluded that the functional state of the blood coagulation system is controlled by the concentration and proportion of oxygen and carbon dioxide, i. e. biologically active gases, in inhaled air and blood.
Related Concept Videos
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Oxygen Transport in the Blood
Hypoxia
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:

