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Diversity of Protists II

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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Post-genomics resources and tools for studying apicomplexan metabolism.

Stacy S Hung¹, John Parkinson

¹Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada.

Trends in Parasitology

|December 15, 2010

Summary

This review examines resources and tools for reconstructing apicomplexan metabolism from genomic data. It prioritizes therapeutic targets for drug development against these significant human parasites.

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Area of Science:

Parasitology
Genomics
Drug Discovery

Background:

Apicomplexa are obligate intracellular parasites causing significant human diseases.
Increasing genomic data offers potential for identifying therapeutic targets.
Metabolic reconstruction is crucial but challenging due to limited biochemical data.

Purpose of the Study:

To review current resources and tools for apicomplexan metabolic reconstruction.
To discuss the utilization of genomic datasets for exploring apicomplexan metabolism.
To prioritize therapeutic targets for drug development.

Main Methods:

Examination of existing bioinformatics resources and tools.
Analysis of apicomplexan genomic data for metabolic pathways.
Prioritization of potential therapeutic targets based on metabolic insights.

Main Results:

Identification of key resources and tools for metabolic reconstruction.
Discussion on strategies for leveraging genomic data.
Prioritization of specific metabolic targets for intervention.

Conclusions:

Effective utilization of genomic data and available tools can facilitate metabolic reconstruction in apicomplexans.
This approach aids in identifying and prioritizing therapeutic targets for drug development against apicomplexan parasites.