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Updated: Jun 6, 2026
10:59
Human Blastocyst Biopsy and Vitrification
Published on: July 26, 2019
Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation
Victor Y Fujimoto1, Richard W Browne, Michael S Bloom
1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94115-0916, USA. fujimotov@obgyn.ucsf.edu
Fertility and Sterility
|December 15, 2010
Summary
Human embryo fragmentation during in vitro fertilization (IVF) is reviewed, highlighting the oocyte's role in its development. Aberrant cell division and membrane instability are proposed mechanisms.
Area of Science:
- Reproductive biology
- Cell biology
- In vitro fertilization (IVF)
Background:
- Human embryo fragmentation is a common issue in IVF.
- Understanding its causes is crucial for improving IVF success rates.
Purpose of the Study:
- To review current knowledge on human embryo fragmentation during IVF.
- To discuss the clinical relevance and pathogenesis of fragmentation.
- To present novel concepts regarding fragmentation mechanisms.
Main Methods:
- Narrative review of existing literature.
- Discussion of clinical relevance.
- Presentation of pathogenetic evidence and proposed mechanisms.
Main Results:
- Evidence suggests a central role for the oocyte in embryo fragmentation.
- Aberrant cell division involving the cytoskeleton is a proposed mechanism.
- Novel concept of membrane instability linked to follicular high-density lipoprotein metabolism and cholesterol transport is introduced.
Conclusions:
- The oocyte plays a significant role in human embryo fragmentation.
- Cytoskeletal dysfunction and membrane instability are key areas for future research in IVF.
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