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Updated: Jun 6, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Autoimmune blistering diseases in the elderly
Sareeta R S Parker1, Jamie MacKelfresh
1Department of Dermatology, Emory University School of Medicine, 1365 Clifton Rd NE, Ste 1100, Building A, Atlanta, GA 30322, USA. srsingh@emory.edu
Clinics in Dermatology
|December 15, 2010
Summary
Autoimmune blistering diseases like bullous pemphigoid are increasing in the elderly. This review covers diagnosis and management of these rare but serious skin conditions in older adults.
Area of Science:
- Dermatology
- Immunology
- Geriatrics
Background:
- Autoimmune blistering diseases significantly impact elderly health.
- Incidence of these disorders, especially bullous pemphigoid, is rising due to population aging.
Purpose of the Study:
- To review autoimmune immunobullous disorders relevant to the elderly.
- To provide an overview of diagnosis, management, and molecular targets.
Main Methods:
- Review of relevant autoimmune immunobullous disorders in the elderly.
- Discussion of clinical features, diagnostic tests, and immunofluorescence microscopy.
- Examination of molecular targets and diagnostic assays.
Main Results:
- Key disorders include bullous pemphigoid, cicatricial pemphigoid, and others.
- Diagnostic accuracy is enhanced by molecular target elucidation and serum assays.
- Therapeutic evidence is limited, and treatments are not standardized.
Conclusions:
- Accurate diagnosis is critical for effective management of autoimmune blistering diseases in the elderly.
- Further research is needed to standardize treatment protocols for these rare conditions.
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