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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Published on: July 19, 2019

Gene expression profiling in multiple sclerosis brain.

Ranjan Dutta1, Bruce D Trapp

  • 1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Neurobiology of Disease
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) is a central nervous system disease causing neurological disability. This review summarizes gene expression data from MS brain tissue studies to understand disease causes.

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Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
  • It is a leading cause of non-traumatic neurological disability in young adults in the US and Europe.
  • MS presents with variable clinical courses, often starting in the third or fourth decade of life.

Purpose of the Study:

  • To review and synthesize findings from large-scale microarray studies on MS brain tissue.
  • To elucidate the genetic underpinnings of multiple sclerosis pathogenesis.
  • To correlate gene expression profiles with the understanding of MS.

Main Methods:

  • Systematic review of existing microarray-based gene expression profiling studies in multiple sclerosis.
  • Analysis of gene expression data from central nervous system tissue of MS patients.
  • Comparative analysis of data from different gene profiling studies.

Main Results:

  • Gene expression profiling provides insights into the molecular mechanisms of MS.
  • Multiple studies reveal distinct gene expression patterns in MS brain tissue.
  • These patterns are crucial for understanding the inflammatory and demyelinating processes in MS.

Conclusions:

  • Gene expression profiling is a valuable tool for understanding multiple sclerosis pathogenesis.
  • Synthesized data from multiple studies enhance our comprehension of MS.
  • Further research integrating gene expression data can advance MS therapeutic strategies.