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Updated: Jun 6, 2026
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Moving forward in human cancer risk assessment
Richard S Paules1, Jiri Aubrecht, Raffaella Corvi
1National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. paules@niehs.nih.gov
Environmental Health Perspectives
|December 15, 2010
Summary
The current cancer risk assessment relies on animal testing, which is costly and has limited human relevance. A new paradigm using genomics and human data offers better mechanistic insights and predictive approaches for human health risk evaluation.
Area of Science:
- Toxicology
- Genomics
- Risk Assessment
Background:
- Current carcinogenicity testing relies on in vitro genotoxicity and 2-year rodent bioassays.
- This paradigm is sensitive but lacks specificity, is costly, and has limited predictive value for human risks.
Framework:
- A workshop convened experts to discuss a paradigm shift in carcinogenicity testing.
- Focus was on developing alternative testing strategies using omics technologies.
Implementation:
- Genomics approaches offer mechanistic insights for predicting human health effects.
- Integrating human data into testing strategies is crucial.
Implications:
- New genomics-based methods can inform predictive approaches and biomarkers.
- Regulators are open to novel approaches with clear definitions and strong evidence.
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