Related Experiment Video
Updated: Jun 6, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
Paraneoplastic cerebellar degeneration mimicking development of secondary progressive multiple sclerosis in a patient
Rm Gracien1, M Kordulla, U Ziemann
1Department of Neurology, Goethe-University, Frankfurt am Main, Germany.
Abstract:
Paraneoplastic cerebellar degeneration (PCD) is a rare non-metastatic complication of cancer mediated by T lymphocytes and auto-antibodies directed against Purkinje cells of the cerebellum. We report a patient with relapsing-remitting multiple sclerosis who developed a progressive cerebellar syndrome with dysarthria, ataxic gait and vertigo mimicking development of secondary progressive multiple sclerosis but caused by anti-Yo antibody positive PCD associated with ovarian cancer, presenting an unusual diagnostic challenge.
Related Concept Videos
Multiple Sclerosis l: Introduction
Secondary Spinal Cord Injury llI: Pathophysiology
Parkinson's Disease: Overview
Encephalitis l: Introduction
Neural Regulation

