Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stimulants

Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However, frequent irregular...

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...

Drug Toxicity: Risk factors

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of Dioxin and Dioxin-like Congeners With Hypertension.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2019

Same author

Cryptogenic Stroke: To Close a Patent Foramen Ovale or Not to Close?

Journal of central nervous system disease·2018

Same author

The Utility of Anti-Inflammatory Agents in Cardiovascular Disease: A Novel Perspective on the Treatment of Atherosclerosis.

Journal of cardiovascular pharmacology and therapeutics·2018

Same author

The Need for Extracorporeal Membrane Oxygenation in Adults Undergoing Congenital Heart Surgery: Impact and Trends of Utilization.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2017

Same author

Arrhythmias in Adults with Congenital Heart Disease: What Are Risk Factors for Specific Arrhythmias?

Pacing and clinical electrophysiology : PACE·2016

Same author

Dominant Versus Nondominant Hand Cardiopulmonary Resuscitation: Is There Really True Dominance?

American journal of therapeutics·2016

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

Cocaine and cardiovascular complications.

Sandeep Bhargava¹, Rohit R Arora

¹Department of Cardiology, Chicago Medical School, North Chicago VA Medical Center, North Chicago, IL 60064, USA.

American Journal of Therapeutics

|December 15, 2010

Summary

Cocaine use affects millions, leading to serious cardiovascular complications. This review covers the latest understanding and treatment of these heart issues in cocaine users.

More Related Videos

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference

Published on: July 30, 2013

Related Experiment Videos

Last Updated: Jun 6, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference

Published on: July 30, 2013

Area of Science:

Cardiology
Toxicology
Public Health

Background:

Cocaine abuse affects over 36 million Americans, presenting significant health challenges.
Cardiovascular complications are a major concern associated with both acute and chronic cocaine use.
Increasing cocaine abuse necessitates updated knowledge on its cardiac effects and management.

Purpose of the Study:

To review common cardiovascular complications linked to cocaine use.
To discuss current treatment strategies for cocaine-associated cardiac issues.
To provide an overview of the evolving understanding of cocaine's cardiovascular pathophysiology.

Main Methods:

Literature review of studies on cocaine use and cardiovascular effects.
Synthesis of information on pathophysiology, clinical presentation, and treatment.
Analysis of recent advancements in managing cocaine-induced cardiac complications.

Main Results:

Cocaine use is linked to a wide range of cardiovascular problems.
Treatment approaches are evolving with a better understanding of the underlying mechanisms.
Management requires addressing both the acute cardiac event and long-term substance abuse.

Conclusions:

Cardiovascular complications are a critical aspect of cocaine abuse.
Effective management relies on updated medical knowledge and tailored treatment plans.
Continued research is vital to improve outcomes for individuals with cocaine-associated cardiovascular disease.