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Related Experiment Video

Updated: Jun 6, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

Focus Issue on Squamous Cell Carcinoma: Practical Concerns Regarding the 7th Edition AJCC Staging Guidelines.

D Buethe¹, C Warner, J Miedler

¹Department of Dermatology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9191, USA.

Journal of Skin Cancer

|December 15, 2010

Summary

The 7th edition AJCC manual updates cutaneous squamous cell carcinoma (cSCC) staging using evidence-based medicine. While improving patient stratification, some guidelines need clarification for clinical practice.

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Area of Science:

Oncology
Dermatology
Cancer Staging

Background:

The 7th edition AJCC Cancer Staging Manual introduces evidence-based medicine for cutaneous squamous cell carcinoma (cSCC) staging.
Previous editions lacked comprehensive, evidence-based guidelines for cSCC.
This marks a significant shift towards improved clinical decision-making.

Purpose of the Study:

To review key changes in cSCC staging from the 6th to the 7th edition AJCC manual.
To identify impractical aspects and areas needing clarification in the 7th edition guidelines.
To propose recommendations for improving future editions of the staging manual.

Main Methods:

Comparative analysis of the 6th and 7th editions of the AJCC Cancer Staging Manual concerning cSCC.

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Last Updated: Jun 6, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

Focused review on specific changes: separate guidelines for cSCC and Merkel cell carcinoma (MCC), high-risk factor incorporation, advanced T stage guidelines, and lymph node status stratification.

Modification of a comprehensive review on nonmelanoma skin cancer staging.

Main Results:

The 7th edition incorporates separate staging for cSCC and MCC.
High-risk factors are now used as T stage modifiers.
New guidelines for advanced T stage and revised lymph node stratification are introduced.

Conclusions:

The 7th edition represents a significant improvement in cSCC staging, enhancing patient stratification and prognostic accuracy.
Certain aspects of the 7th edition require clarification and practical adjustments for clinical implementation.
Recommendations are provided to address current shortcomings and refine future staging guidelines.