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Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
Published on: August 29, 2016
LIVER TRANSPLANTATION IN MAN
Israel Penn1, Charles G Halgrimson, Thomas E Starzl
1Department of Surgery, University of Colorado School of Medicine and the Denver Veterans Administration Hospital, Denver, Colo.
Annals of the New York Academy of Sciences
|December 15, 2010
Summary
Liver transplantation shows promise for incurable liver disease, with six patients surviving over a year post-operation. Despite high mortality, its future role may mirror kidney transplantation success.
Area of Science:
- Hepatology
- Transplant Surgery
- Medical Innovation
Background:
- Historically, opinions on liver transplantation for end-stage liver disease were tentative.
- Recent advancements allow for a more authoritative stance on clinical liver transplantation.
Purpose of the Study:
- To justify an optimistic outlook on liver transplantation for hepatic diseases.
- To outline indications for liver transplantation based on recent experience.
- To analyze technical and judgmental errors contributing to early mortality.
Main Methods:
- Review of clinical outcomes for patients undergoing liver transplantation.
- Analysis of surgical techniques and decision-making processes.
- Comparison with historical data from renal transplantation.
Main Results:
- Six patients achieved over one year of survival following cadaveric liver transplantation.
- High mortality rates were observed, similar to early renal transplantation trials.
- Identification of key errors in technique and judgment impacting patient survival.
Conclusions:
- Liver transplantation is emerging as a viable, albeit challenging, treatment for incurable liver disease.
- The future role of liver transplantation is anticipated to parallel that of kidney transplantation.
- Learning from past errors is crucial for improving outcomes in liver transplantation.
