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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

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Focus on Basal cell carcinoma.

Venura Samarasinghe¹, Vishal Madan, John T Lear

¹Manchester Royal Infirmary, Central Manchester and Manchester Childrens' Hospital NHS Trust, Oxford Road, Manchester M13 9WL, UK.

Journal of Skin Cancer

|December 15, 2010

Summary

Basal cell carcinoma (BCC) is a common skin cancer influenced by sun exposure and other factors. Research explores its pathogenesis and management, including newer non-invasive treatments beyond surgical excision.

Area of Science:

Dermatology
Oncology

Background:

Nonmelanoma skin cancers (NMSCs), primarily basal cell carcinoma (BCC) and squamous cell carcinoma, are the most prevalent human cancers.
BCC, characterized by slow growth and low metastatic potential, is often underreported despite significant public health impact due to high prevalence and multifocal occurrences.
While sun exposure is a key factor, BCC development involves complex interactions of genotypic, phenotypic, and environmental influences.

Purpose of the Study:

To review the pathogenesis of basal cell carcinoma (BCC).
To discuss current and emerging management strategies for BCC.
To highlight the need for effective, tissue-sparing therapies.

Main Methods:

Literature review focusing on BCC pathogenesis.
Analysis of established and investigational BCC treatment modalities.

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Synthesis of information on risk factors and clinical management.

Main Results:

Sun exposure is a significant contributor to BCC development.
Multiple factors including genetic and environmental elements play a role in BCC pathogenesis.
Surgical excision is the primary treatment, with photodynamic therapy and topical imiquimod as established non-invasive options for specific subtypes.

Conclusions:

Understanding BCC pathogenesis is crucial for developing targeted therapies.
There is an ongoing need for innovative, non-invasive treatments that are both effective and preserve tissue.
Multifaceted approaches are required for comprehensive BCC management.