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Related Experiment Video

Updated: Jun 6, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Lithium nephrotoxicity.

Jobson Lopes de Oliveira1, Geraldo Bezerra da Silva Júnior, Krasnalhia Lívia Soares de Abreu

  • 1Universidade Federal do Ceará, Fortaleza, CE, Brazil.

Revista Da Associacao Medica Brasileira (1992)
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Lithium treatment for bipolar disorder can cause kidney damage, including impaired urine concentration and chronic kidney disease. Early detection and monitoring are crucial for managing lithium-induced nephrotoxicity.

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A Protocol for Safe Lithiation Reactions Using Organolithium Reagents
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

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Published on: July 3, 2013

A Protocol for Safe Lithiation Reactions Using Organolithium Reagents
09:45

A Protocol for Safe Lithiation Reactions Using Organolithium Reagents

Published on: November 12, 2016

Area of Science:

  • Nephrology
  • Psychiatry
  • Pharmacology

Background:

  • Lithium is a cornerstone treatment for bipolar disorder.
  • Lithium therapy is associated with significant renal toxicity.
  • Nephrotoxicity is a major concern limiting long-term lithium use.

Purpose of the Study:

  • To review the pathogenesis of lithium-induced nephrotoxicity.
  • To describe the clinical presentation and histopathological findings.
  • To discuss current and emerging treatment strategies for kidney damage caused by lithium.

Main Methods:

  • Literature review of experimental and clinical studies.
  • Analysis of data on lithium's effects on renal function.
  • Synthesis of information on mechanisms, diagnosis, and management.

Main Results:

  • Common adverse effects include nephrogenic diabetes insipidus (20-40% of patients).
  • Chronic kidney disease can develop, correlating with treatment duration.
  • Mechanisms of lithium-induced renal changes are increasingly understood.

Conclusions:

  • Lithium-induced nephrotoxicity is a spectrum of renal damage.
  • Rigorous patient monitoring and interdisciplinary collaboration are essential.
  • Understanding the pathogenesis aids in preventing and treating kidney dysfunction.