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Updated: Jun 6, 2026
11:04
Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor (IRIS)
Published on: May 3, 2011
IRBIT: it is everywhere
Dongki Yang1, Nikolay Shcheynikov, Shmuel Muallem
1Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda, MD 20892, USA.
Neurochemical Research
|December 15, 2010
Summary
IRBIT is a versatile protein that inhibits IP(3) receptors and regulates bicarbonate transporters and mRNA processing. This review explores its diverse functions, suggesting more await discovery.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- IRBIT (IP(3)Rs binding protein released with IP(3)) was initially identified as an inhibitor of IP(3) receptors.
- Recent findings reveal IRBIT's involvement in a broader range of cellular processes.
- Understanding IRBIT's multifaceted roles is crucial for comprehending cellular regulation.
Purpose of the Study:
- To provide a comprehensive overview of the diverse functions of IRBIT.
- To highlight IRBIT's roles beyond IP(3) receptor inhibition.
- To emphasize the potential for further discoveries regarding IRBIT's functions.
Main Methods:
- Literature review of studies on IRBIT.
- Analysis of experimental data on IRBIT's interactions and functions.
- Synthesis of information on IRBIT's regulatory roles in different cellular pathways.
Main Results:
- IRBIT regulates epithelial bicarbonate secretion by modulating HCO(3)(-) transporters.
- IRBIT influences mRNA processing by controlling the localization of the Fip1 subunit of the CPSF complex.
- IRBIT exhibits a wide array of functions, indicating significant biological importance.
Conclusions:
- IRBIT possesses remarkably diverse functions, extending far beyond its initial identification.
- The known functions of IRBIT represent only a portion of its complete biological repertoire.
- Further research is warranted to fully elucidate the scope of IRBIT's activities and regulatory capabilities.
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